| Autor: |
Turner-Stokes, Lynne, Jacinto, Jorge, Fheodoroff, Klemens, Brashear, Allison, Maisonobe, Pascal, Lysandropoulos, Andreas, Ashford, Stephen on behalf of the Upper Limb International Spasticity-III (ULIS-III) study group( Australia: Ian Baguley, Arun, Aggarwal, John, Olver, John, Estell, Steven, Faux, Edwin, Luk, Katya, Kotschet, Andrew, Hughes, Austria and Germany: Bernhard Haslinger, Rachael Nunan., Petra, Baum, Cornelia, Mobius, Urban, Fietzek, Brazil: Tae Mo Chung, Chi Wang Ip., Régina Helena Chueire, France: Alexis Schnitzler, Carla Heloisa Cabral Moro., Claire, Delleci, Anne-Laure, Ferrapie, Marie-Eve, Isner-Horobeti, Italy: Michela Cosma, Dominic Perennou. Hong Kong: Ching Man Leung., Carlo, Caltagirone, Manuela, Diverio, Girlanda, Paolo, Giancarlo, Ianeri, Marzia, Millevolte, Mexico: Jorge Hernandez Franco, Franco Molteni., Juan Francisco Gomez Hernandez, Sandra Quinones Aguilar, Philippines: Raymond Rosales, Laura Patricia De La Lanza Andrade., Poland: Dariusz Koziorowski, Jeanne Flordelis., Anna, Potulska, Portugal: Eduarda Afonso, Monika Rudzinska., Russia: Svetlana Khatkova, Ana Rolo Duarte., Alexey, Korenko, Dina, Khasanova, Dmitry, Okhabov, Elena, Arefyeva, Denis, Karpov, Taiwan: Yi-Chung Lee, Andrey Korolev., USA: Jessica Tate, Sen-Wei Tsai., Davis, Thomas L., Cynthia, Marciniak, Atul, Patel. ). |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Rehabilitation Medicine, Vol 53, Iss 2, p jrm00157 (2021) |
| ISSN: |
1651-2081 |
| DOI: |
10.2340/16501977-2801 |
| Popis: |
Objective To assess the longitudinal effects of integrated spasticity management incorporating repeated cycles of botulinum toxin A type A (BoNT-A) over 2 years. Methods The Upper Limb International Spasticity study was a prospective, observational, cohort study following adult patients over 2 years of integrated upper-limb spasticity management including repeat botulinum toxin (BoNT-A) treatment (any commercially-available product). Results A total of 1,004 participants from 14 countries were enrolled, of which 953 underwent ≥ 1 BoNT-A injection cycle (median 4 cycles) and had ≥ 1 goal attainment scaling assessment. Most participants (55.9-64.6% across cycles 1-6) saw a therapist after BoNT-A treatment; the most frequent therapy intervention was passive stretch (70.1-79.8% across cycles 1-6). Patients achieved their goals as expected over repeated cycles; mean cumulated goal attainment scaling T-score at 2 years was 49.5 (49.1, 49.9). Mean goal attainment scaling change scores of ≥ 10 were maintained across up to 7 cycles. Higher rates of goal achievement were seen for primary goals related to passive vs active function (86.6% vs 71.4% achievement). Standardized measures of spasticity, pain, involuntary movements, active and passive function improved significantly over the study. Conclusion This large, international study provides evidence for benefit of repeated cycles of BoNT-A, over 2 years captured through person-centred goal attainment and standardized measures. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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