Toxicogenetic assessment of a pre-workout supplement: In vitro mutagenicity, cytotoxicity, genotoxicity and glutathione determination in liver cell lines and in silico ADMET approaches

Autor:	Eduardo Kennedy Carrão Dantas, Carlos Fernando Araújo-Lima, Caroline Lopes Simões Ferreira, Alana da Cunha Goldstein, Cláudia Alessandra Fortes Aiub, Marsen Garcia Pinto Coelho, Israel Felzenszwalb
Rok vydání:	2022
Předmět:	Liver Mutagenicity Tests Health Toxicology and Mutagenesis Genetics Glutathione Toxicogenetics Cell Line DNA Damage Mutagens
Zdroj:	Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :503517
ISSN:	1383-5718
DOI:	10.1016/j.mrgentox.2022.503517
Popis:	The benefits of practicing physical activity, such as weight loss and control, are commonly associated with caloric restriction diets and may be improved by the ingestion of thermogenic and ergogenic supplements. However, there is a lack of safety data on commonly marketed nutritional supplements. Therefore, this investigation aims to evaluate a pre-workout supplement for mutagenicity using the Ames test, hepatocytoxicity in HepG2 and F C3H cells after 24 h, 48 h and 72 h, genotoxicity using the CBMN assay, determination of gluthatione activity and computational prediction of the three major isolated compounds present in the supplement. The mutagenicity test showed a mutagenic response in TA98 His
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa3dca1690c6dd1cd60107c0d79dcdb https://doi.org/10.1016/j.mrgentox.2022.503517 Zobrazit plný text záznamu Full Text from ScienceDirect