Dairy Products, Dietary Calcium and Vitamin D Intake as Risk Factors for Prostate Cancer: A Meta-Analysis of 26,769 Cases From 45 Observational Studies
Autor: | Bruce Kupelnick, Joshua E. Muscat, Michael Huncharek |
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Rok vydání: | 2008 |
Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Medicine (miscellaneous) Adenocarcinoma Cohort Studies Prostate cancer Risk Factors Internal medicine Odds Ratio Vitamin D and neurology Humans Medicine Vitamin D Randomized Controlled Trials as Topic Nutrition and Dietetics business.industry Prostatic Neoplasms Middle Aged Micronutrient medicine.disease Confidence interval Calcium Dietary Endocrinology Case-Control Studies Relative risk Meta-analysis Observational study Dairy Products business Cohort study |
Zdroj: | Nutrition and Cancer. 60:421-441 |
ISSN: | 1532-7914 0163-5581 |
Popis: | In this study, we examined the available evidence and sources of heterogeneity for studies of dairy products, calcium, and vitamin D intake and the risk of prostate cancer. We pooled data from 45 observational studies using a general variance-based, meta-analytic method employing CIs. Summary relative risks (RRs) were calculated for specific dairy products such as milk and dairy micronutrients. Sensitivity analyses were performed to test the robustness of these summary measures of effect. Cohort studies showed no evidence of an association between dairy [RR = 1.06; 95% confidence interval (CI) = 0.92-1.22] or milk intake (RR = 1.06; 95% CI = 0.91-1.23) and risk of prostate cancer. This was supported by pooled results of case-control analyses (RR = 1.14; 95% CI = 1.00-1.29), although studies using milk as the exposure of interest were heterogeneous and could not be combined. Calcium data from cohort studies were heterogeneous. Case-control analyses using calcium as the exposure of interest demonstrated no association with increased risk of prostate cancer (RR = 1.04; 95% CI = 0.90-1.15). Dietary intake of vitamin D also was not related to prostate cancer risk (RR = 1.16; 95% CI = 0.98-1.38). The data from observational studies do not support an association between dairy product use and an increased risk of prostate cancer. |
Databáze: | OpenAIRE |
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