Milk-Alkali Syndrome Associated with Calcium Carbonate Consumption: Report of 7 Patients with Parathyroid Hormone Levels and an Estimate of Prevalence Among Patients Hospitalized with Hypercalcemia
| Autor: | D P Beall, Scofield Rh |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases Osteoporosis Parathyroid hormone Malignancy Gastroenterology Calcium Carbonate Internal medicine medicine Humans Multiple myeloma Aged Retrospective Studies Aged 80 and over Hyperparathyroidism business.industry Retrospective cohort study General Medicine Middle Aged Milk-alkali syndrome medicine.disease Hospitalization Endocrinology Parathyroid Hormone Hypercalcemia Female Immunoradiometric Assay business hormones hormone substitutes and hormone antagonists Primary hyperparathyroidism |
| Zdroj: | Medicine. 74:89-96 |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/00005792-199503000-00004 |
| Popis: | Milk-alkali syndrome can be caused by ingesting large amounts of calcium carbonate. Coincident with the promotion of calcium carbonate as treatment for both dyspepsia and osteoporosis, milk-alkali syndrome is now a common cause of hypercalcemia severe enough to require admission to the hospital. The syndrome accounted for less than 2% of such admissions before 1990, but from 1990 through 1993, it was the cause of hypercalcemia for over 12% of these patients. Only primary hyperparathyroidism and hypercalcemia of malignancy (excluding multiple myeloma) are more common. The diagnosis of milk-alkali syndrome is made almost entirely based on the patient's history; careful attention to dietary practices and over-the-counter drug use is required, as numerous over-the-counter medications contain calcium carbonate. Modern assays for PTH demonstrate the expected suppression of PTH by hypercalcemia. Nonetheless, measurement of PTH must be performed in a timely manner as treatment with intravenous saline may result in hypocalcemia and elevated PTH soon after admission. Given the pathophysiology of milk-alkali syndrome compared to other causes of hypercalcemia, hypocalcemia with rebound hyperparathyroidism is probably unique to milk-alkali syndrome. |
| Databáze: | OpenAIRE |
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