High plasma fetuin-A levels are associated with metabolic syndrome among males but not females in a Japanese general population
| Autor: | Ayako Yoshimura, Yume Nohara, Ako Fukami, Eita Kumagai, Erika Nakao, Sachiko Nakamura, Yoshihiro Fukumoto, Hisashi Adachi, Mika Enomoto, Aya Obuchi, Tsutomu Imaizumi, Yoko Umeki |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty alpha-2-HS-Glycoprotein Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Enzyme-Linked Immunosorbent Assay Cohort Studies Sex Factors Endocrinology Insulin resistance Asian People Japan Diabetes mellitus Internal medicine Odds Ratio Prevalence Internal Medicine medicine Humans Insulin education Aged Metabolic Syndrome education.field_of_study business.industry General Medicine Odds ratio Middle Aged Stepwise regression medicine.disease Cross-Sectional Studies Quartile Female alpha-Fetoproteins Insulin Resistance Metabolic syndrome business Biomarkers |
| Zdroj: | Diabetes Research and Clinical Practice. 106:128-135 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2014.07.002 |
| Popis: | Aims Fetuin-A, a protein exclusively secreted from the liver, is associated with insulin resistance and/or metabolic syndrome (MetS). However, few studies have examined this association in Japan. We investigated this issue in a Japanese general population. Methods We performed an epidemiological survey in a small community in Japan. The participants consisted of 659 subjects (253 males and 406 females). Fetuin-A levels were measured by a sandwich ELISA method and the modified NCEP-ATP III criteria were adopted to diagnose MetS. The homeostasis model assessment index (HOMA-IR) was calculated as a marker of insulin resistance. Results Statistically significant characteristics of the 659 subjects stratified by fetuin-A quartiles were male gender (inversely), age (inversely), insulin, HOMA-IR, uric acid (inversely), alcohol intake (inversely) and the prevalence of MetS. Mean fetuin-A levels were 249.7 ± 45.1 μg/ml in males and 262.7 ± 55.8 μg/ml in females. In males, the prevalence of MetS was 43.1%, and their mean HOMA-IR level was 1.1. In females, the prevalence of MetS was 17.7%, and their mean HOMA-IR level was 0.9. Multiple stepwise regression analyses showed that fetuin-A levels in males but not females were independently associated with MetS and LDL-c. Multiple logistic regression analysis of fetuin-A (quartile 1 vs. quartile 4) in males showed significant odds ratios of 1.009 (95% C.I.: 1.003–1.015) for MetS and 1.376 (95% C.I.: 1.027–1.844) for 1-SD increment increase in LDL-c. Conclusions High plasma fetuin-A levels were associated with MetS in community-dwelling Japanese males but not females. |
| Databáze: | OpenAIRE |
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