Skeletal Effects of Cholesterol Feeding
| Autor: | Ruth Silberberg |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Physiology Male mice Articular cartilage DISC PROLAPSE Pathology and Forensic Medicine Cholesterol Dietary Spinal Osteophytosis Mice chemistry.chemical_compound Cholesterol feeding Osteoarthritis medicine Animals Weaning Molecular Biology Triglycerides Cholesterol business.industry Incidence (epidemiology) Body Weight Cell Biology General Medicine Spine Hindlimb Surgery Mice Inbred C57BL chemistry Standard diet Joints business Intervertebral Disc Displacement |
| Zdroj: | Pathobiology. 43:265-275 |
| ISSN: | 1423-0291 1015-2008 |
| Popis: | The effect of a 4% supplement of cholesterol to a standard diet on knee joints and vertebral columns was investigated in male mice of strain C57B1. The experimental diet was fed from the time of weaning through the 18-month period of observation or from the age of 1 year to the end of the experiment at 18 months of age. The incidence of osteoarthrosis was increased in mice fed cholesterol from the age of 12 months on. The incidence of spondylosis was increased after lifelong feeding as well as after feeding of cholesterol during the second year of life. This increase involved both, spondylosis associated with or uncomplicated by prolapse of intervertebral discs. The incidence of simple disc prolapse was not affected by the experimental diet. |
| Databáze: | OpenAIRE |
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