Relations of Lipid Concentrations to Heart Failure Incidence
| Autor: | William B. Kannel, Joseph M. Massaro, Sander J. Robins, Daniel Levy, Raghava S. Velagaleti, Ramachandran S. Vasan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Population Article Cohort Studies Framingham Heart Study Risk Factors Physiology (medical) Internal medicine Humans Medicine Myocardial infarction Risk factor education Dyslipidemias Heart Failure education.field_of_study business.industry Incidence Incidence (epidemiology) Cholesterol HDL Cholesterol LDL Middle Aged medicine.disease Lipids Endocrinology Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies Cohort study |
| Zdroj: | Circulation. 120:2345-2351 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.109.830984 |
| Popis: | Background— The relations of lipid concentrations to heart failure (HF) risk have not been elucidated comprehensively. Methods and Results— In 6860 Framingham Heart Study participants (mean age, 44 years; 54% women) free of baseline coronary heart disease, we related high-density lipoprotein cholesterol (HDL-C) and non-HDL-C to HF incidence during long-term follow-up, adjusting for clinical covariates and myocardial infarction at baseline and updating these at follow-up examinations. We evaluated dyslipidemia-specific population burden of HF by calculating population attributable risks. During follow-up (mean of 26 years), 680 participants (49% women) developed HF. Unadjusted HF incidence in the low ( Conclusions— Dyslipidemia carries HF risk independent of its association with myocardial infarction, suggesting that lipid modification may be a means for reducing HF risk. |
| Databáze: | OpenAIRE |
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