CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis

Autor: Luiz Carlos de Mattos, Fernando H.A. Murata, Aparecida Perpétuo Silveira-Carvalho, Alessandro Garcia Lopes, Amanda Pires Barbosa, Rubens Camargo Siqueira, Christiane Maria Ayo, Fábio Batista Frederico, Cinara Cássia Brandão de Mattos, Mariana Previato, Amanda Priscila de Oliveira, Geraldo Magela de Faria Junior, Gildásio Castello de Almeida Júnior
Přispěvatelé: Faculdade de Medicina de São José do Rio Preto (FAMERP), Ophthalmology Outpatient Clinic of Hospital de Base da Fundação Faculdade Regional de Medicina de São José do Rio Preto (HB– FUNFARME), Universidade Estadual Paulista (Unesp), Medical Specialties Outpatient Clinic of Hospital Estadual 'João Paulo II' (AME)
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Aging
Chemokine receptor CCR5
Ocular toxoplasmosis
CCR5 receptor
Polymerase Chain Reaction
Gastroenterology
Serology
Chemokine receptor
0302 clinical medicine
Risk Factors
Genotype
Aged
80 and over
biology
Middle Aged
Infectious Diseases
Female
Chemokines
Toxoplasma
Polymorphism
Restriction Fragment Length
Adult
medicine.medical_specialty
Adolescent
Receptors
CCR5
Veterinary (miscellaneous)
Toxoplasma gondii
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Toxoplasmosis
Ocular
Aged
Genetic polymorphism
Polymorphism
Genetic
business.industry
biology.organism_classification
medicine.disease
Chemokine Receptor Gene
Toxoplasmosis
030104 developmental biology
Case-Control Studies
Insect Science
030221 ophthalmology & optometry
biology.protein
Parasitology
CC chemokine receptors
business
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0001-706X
DOI: 10.1016/j.actatropica.2017.12.012
Popis: Made available in DSpace on 2018-12-11T17:16:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-02-01 C–C chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Δ32 and CCR5 59029 A/G polymorphisms are associated with the development of ocular toxoplasmosis in humans. Patients with positive serology for Toxoplasma gondii were analyzed and grouped as ‘with ocular toxoplasmosis’ (G1: n = 160) or ‘without ocular toxoplasmosis’ (G2: n = 160). A control group (G3) consisted of 160 individuals with negative serology. The characterization of the CCR5Δ32 and CCR5 59029 A/G polymorphisms was by PCR and by PCR-RFLP, respectively. The difference between the groups with respect to the mean age (G1: mean age: 47.3, SD ± 19.3, median: 46 [range: 18–95]; G2: mean age: 61.3, SD ± 13.7, median: 61 [range: 21–87]; G3: mean age: 38.8, SD ± 17.9, median: 34 [range: 18–80]) was statistically significant (G1 vs.G2: p-value
Databáze: OpenAIRE
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