Ertapenem administered as outpatient parenteral antibiotic therapy for urinary tract infections caused by extended-spectrum- -lactamase-producing Gram-negative organisms
Autor: | Ann L N Chapman, T. G. Winstanley, Rohit Bazaz |
---|---|
Rok vydání: | 2010 |
Předmět: |
Adult
Ertapenem Male Microbiology (medical) medicine.medical_specialty medicine.drug_class Urinary system Antibiotics beta-Lactams beta-Lactamases chemistry.chemical_compound Pharmacotherapy Antibiotic resistance Internal medicine Gram-Negative Bacteria Ambulatory Care medicine Humans Pharmacology (medical) Infusions Intravenous Aged Retrospective Studies Antibacterial agent Pharmacology business.industry Retrospective cohort study Health Care Costs Middle Aged United Kingdom Anti-Bacterial Agents Surgery Treatment Outcome Infectious Diseases chemistry Urinary Tract Infections Ambulatory Female Gram-Negative Bacterial Infections business |
Zdroj: | Journal of Antimicrobial Chemotherapy. 65:1510-1513 |
ISSN: | 1460-2091 0305-7453 |
Popis: | Infections with extended-spectrum-beta-lactamase-producing organisms are an increasing public health concern. We reviewed the use of an outpatient parenteral antibiotic therapy (OPAT) programme to facilitate the early discharge from hospital of patients with ESBL-associated urinary tract infections.A retrospective review of patients treated for urinary tract infections caused by ESBL-producing organisms through the OPAT programme at the Royal Hallamshire Hospital, Sheffield, UK over a 4 year period to January 2010 was conducted. Data on patient demographics, clinical presentation and laboratory results were collected.Twenty-four OPAT episodes involving 11 patients were identified. Six patients (54.5%) had an underlying urological abnormality on presentation to OPAT. All patients were treated with parenteral ertapenem. Two patients had multiple infections treated by OPAT. The mean duration of the OPAT episodes was 9.9 days (range 3-42). A total of 238 inpatient bed days were avoided, with resultant cost savings.Ertapenem administration through OPAT may help to decrease the costs associated with ESBL infections by reducing the number of inpatient bed days required for their successful treatment. |
Databáze: | OpenAIRE |
Externí odkaz: |