Evolution of sinonasal clinical features in children with cystic fibrosis
| Autor: | Ruben Hermann, Eric Truy, P. Suy, S Ayari-Khalfallah, S. Vrielynck, A. Coudert |
|---|---|
| Přispěvatelé: | Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Integrative, Multisensory, Perception, Action and Cognition Team [Bron] (IMPACT), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
Male
Nasal cavity Pediatrics medicine.medical_specialty Adolescent Cystic Fibrosis Rhinosinusitis [SDV]Life Sciences [q-bio] Physical examination Cystic fibrosis 03 medical and health sciences Polyps 0302 clinical medicine 030225 pediatrics medicine Humans Sinusitis Sinus Child 030223 otorhinolaryngology Sinus (anatomy) Retrospective Studies medicine.diagnostic_test business.industry Snoring Retrospective cohort study General Medicine Prognosis medicine.disease 3. Good health medicine.anatomical_structure Otorhinolaryngology Child Preschool Pediatrics Perinatology and Child Health Disease Progression Female Observational study Nasal Cavity Nasal Obstruction business |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology International Journal of Pediatric Otorhinolaryngology, Elsevier, 2019, 124, pp.47-53. ⟨10.1016/j.ijporl.2019.05.030⟩ |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2019.05.030 |
| Popis: | International audience; Objective: to assess the evolution of sinonasal manifestations in children with cystic fibrosis, since the improvement of their prognosis over the last decades.Methods: an observational, monocentric study with a retrospective cohort. We included 173 children (from 4 to 18 years old) with cystic fibrosis followed at the pediatric cystic fibrosis center of lyon, france. We collected respiratory, infectious and nutritional data, sinonasal complaints and physical examination at the onset of sinonasal symptoms (t-0), at the most severe of evolution (t-max) and at the end of followup (t-end).Results: sinonasal symptomatology appeared early around 5.4 years old, then rapidly reached the maximum at 6.9 years and finally improved during childhood (p < 0.0001), reaching scores at t-end significantly better than at t-0 (p < 0.0001). This evolution was significant for nasal obstruction, rhinorrhea and snoring. The other symptoms were rarer, with no significant 38,7% at t-max (p < 0.0001), and 29,5% at t-end (p = 0.52). The lildholdt score, turbinate hypertrophy and medial bulging of medial wall of the maxillary sinus followed the same evolution (p < 0.003). There was no association between sinonasal evolution and cystic fibrosis disease at infectious, respiratory or nutritional level.Conclusion: it is the only recent study evaluating the evolution of each sinonasal manifestations in children with cystic fibrosis. Rhinosinusitis improved during childhood, reaching better scores than at the beginning of management. This particular improvement may be related to good effectiveness to ent management, but also to a positive effect of nasal cavity growth, independently to extra-ent manifestations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect