Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly

Autor: Robert S. Wilson, Dolly Reyes-Dumeyer, Walter A. Kukull, Richard Mayeux, Nicole Schupf, David A. Bennett, Seonjoo Lee, Yizhe Gao, Adam M. Brickman, Denis A. Evans, Xingtao Zhou, Badri N. Vardarajan, Lilah M. Besser, Kumar B. Rajan, Sandra Barral
Přispěvatelé: Ginsberg, Stephen D
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Longitudinal study
Aging
Neurology
Physiology
Ethnic group
Neurodegenerative
Alzheimer's Disease
0302 clinical medicine
Cognition
Learning and Memory
Elderly
80 and over
Medicine and Health Sciences
Ethnicities
Longitudinal Studies
10. No inequality
Episodic memory
Cognitive Impairment
Aged
80 and over
Multidisciplinary
Cognitive Neurology
Incidence (epidemiology)
Incidence
05 social sciences
Age Factors
Neurodegenerative Diseases
Neurological
Memory Recall
Medicine
Educational Status
Female
Episodic
Research Article
medicine.medical_specialty
Genotype
General Science & Technology
Science
Cognitive Neuroscience
Memory
Episodic
and over
050105 experimental psychology
03 medical and health sciences
Apolipoproteins E
Sex Factors
Clinical Research
Memory
Alzheimer Disease
Mental Health and Psychiatry
Acquired Cognitive Impairment
Genetics
medicine
Dementia
Humans
0501 psychology and cognitive sciences
Brain aging
Alleles
Aged
Recall
business.industry
Prevention
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Biology and Life Sciences
medicine.disease
Brain Disorders
Age Groups
People and Places
Cognitive Science
Population Groupings
business
Physiological Processes
Organism Development
030217 neurology & neurosurgery
Demography
Neuroscience
Developmental Biology
Follow-Up Studies
Zdroj: PLoS ONE
PloS one, vol 13, iss 11
PLoS ONE, Vol 13, Iss 11, p e0206803 (2018)
ISSN: 1932-6203
Popis: Age-related changes in memory are not uniform, even in the absence of dementia. Characterization of non-disease associated cognitive changes is crucial to gain a more complete understanding of brain aging. Episodic memory was investigated in 13,037 ethnically diverse elderly (ages 72 to 85 years) with two to 15 years of follow-up, and with known dementia status, age, sex, education, and APOE genotypes. Adjusted trajectories of episodic memory performance over time were estimated using Latent Class Mixed Models. Analysis was conducted using two samples at baseline evaluation: i) non-cognitively impaired individuals, and ii) all individuals regardless of dementia status. We calculated the age-specific annual incidence rates of dementia in the non-demented elderly (n = 10,220). Two major episodic memory trajectories were estimated: 1) Stable-consisting of individuals exhibiting a constant or improved memory function, and 2) Decliner-consisting of individuals whose memory function declined. The majority of the study participants maintain their memory performance over time. Compared to those with Stable trajectory, individuals characterized as Decliners were more likely to have non-white ethnic background, fewer years of education, a higher frequency of ε4 allele at APOE gene and five times more likely to develop dementia. The steepest decline in episodic memory was observed in Caribbean-Hispanics compared to non-Hispanic whites (p = 4.3 x 10(-15)). The highest incident rates of dementia were observed in the oldest age group, among those of Caribbean-Hispanics ancestry and among Decliners who exhibited rates five times higher than those with Stable trajectories (11 per 100 person-years versus 3 per 100 person-years. Age, education, ethnic background and APOE genotype influence the maintenance of episodic memory. Declining memory is one of the strongest predictors of incident dementia.
Databáze: OpenAIRE
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