Plasma neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury after cardio-pulmonary bypass in pediatric cardiac surgery
| Autor: | Mona H. Ibrahim, Zeinab S. Sleem, Fatina I. Fadel, Hafez M. Bazaraa, Azza M. O. Abdel Rahman, Sonia Adolf Habib, Mohamed Farouk Mohamed, Mohamed M.A. Soliman |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
pediatrics Urology Lipocalin law.invention chemistry.chemical_compound Clinical Research law medicine Cardiopulmonary bypass Creatinine business.industry Acute kidney injury neutrophil gelatinase-associated lipocalin General Medicine Venous blood medicine.disease Cardiac surgery Surgery acute kidney injury chemistry biomarker Biomarker (medicine) business Complication cardio-pulmonary bypass |
| Zdroj: | Archives of Medical Science : AMS |
| ISSN: | 1734-1922 |
| DOI: | 10.5114/aoms.2012.28552 |
| Popis: | Introduction Cardiopulmonary bypass (CPB) surgery is considered one of the most frequent surgical procedures in which acute kidney injury (AKI) represents a frequent and serious complication. The aim of the present study was to evaluate the efficiency of neutrophil gelatinase-associated lipocalin (NGAL) as an early AKI biomarker after CPB in pediatric cardiac surgery. Material and methods The study included forty children aged 2 to 78 months undergoing CPB. They were divided into group I: patients who suffered AKI grades II and III; and group II: patients who did not develop AKI or at risk. Peripheral venous blood was withdrawn pre- and post-operatively for serial measurements of NGAL and creatinine. Statistical analysis was performed using Statistical Package for Social Sciences version 14. Results Mean plasma NGAL levels showed highly significant elevations in group I patients at 2, 12, and 24 h after surgery (p < 0.0001) compared to group II. Significant correlations were found between NGAL and creatinine at different time intervals. Highly significant correlations (p < 0.0001) were found between plasma NGAL and AKI at 2, 12 and 24 h after surgery. A cut-off level of 100 ng/ml at 2 h, and 125 ng/ml at 12 h post-operatively both recorded the highest accuracy, being 95% accurate, with sensitivity of 100% and 89.5% respectively, and specificity of 90.5% and 100% respectively. Conclusions This study showed that plasma NGAL could be used as an early biomarker for detection of AKI following CPB. We recommend further studies on a wider scale to validate the current study results. |
| Databáze: | OpenAIRE |
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