The Use of Sonophoresis in the Administration of Drugs Throughout the Skin
| Autor: | Clara Luisa Domínguez-Delgado, Martha Angélica Villegas-González, Dalia Bonilla-Martínez, José Juan Escobar-Chávez, Isabel Marlen Rodríguez-Cruz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Medical diagnostic
Chemistry Pharmaceutical Skin Absorption lcsh:RS1-441 Pharmaceutical Science Pharmacology Administration Cutaneous Permeability lcsh:Pharmacy and materia medica Structure-Activity Relationship Drug Delivery Systems Stratum corneum medicine Transdermal Skin Ultrasonography integumentary system lcsh:RM1-950 Sonophoresis lcsh:Therapeutics. Pharmacology medicine.anatomical_structure Pharmaceutical Preparations Drug Design Drug delivery Drug release Ultrasonic Surgery Medical therapy Biomedical engineering |
| Zdroj: | Journal of Pharmacy & Pharmaceutical Sciences, Vol 12, Iss 1 (2009) |
| ISSN: | 1482-1826 |
| DOI: | 10.18433/j3c30d |
| Popis: | Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. Ultrasound has been used extensively for medical diagnostics and to a certain extent in medical therapy (physiotherapy, ultrasonic surgery, hyperthermia). Nevertheless, it has only recently become popular as a technique to enhance drug release from drug delivery systems. A number of studies suggest the use of ultrasound as an external mean of delivering drugs at increased rates and at desired times. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and trends in the field of topical and transdermal delivery. |
| Databáze: | OpenAIRE |
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