Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database
| Autor: | Diego Pérez Parente, L. Crama, Begoña Campos-Balea, David Vicente-Baz, Pedro Ruiz-Gracia, Manuel Cobo Dols, Javier de Castro Carpeño, Bartomeu Massuti |
|---|---|
| Přispěvatelé: | [Campos-Balea,B] Oncology, Hospital Universitario Lucus Augusti (HULA), Lugo, Spain. [de Castro Carpeño,J] Oncology, Hospital Universitario La Paz, Madrid, Spain. [Massutí,B] Oncology, Hospital Universitario Alicante (ISABIAL), Alicante, Spain. [Vicente-Baz,D] Oncology, Hospital Universitario Virgen Macarena, Seville, Spain. [Pérez Parente, Ruiz-Gracia,P, Crama,L] Lung Cancer. Medical Affairs Department, Roche Farma S.A, Madrid, Spain. [Cobo Dols,M] Medical Oncology, Unidad de Gestión Clínica Intercentros de Oncología Médica. Hospitales Universitarios Regional y Virgen de la Victoria. IBIMA, Málaga, Spain. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Lung adenocarcinoma Male Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Registries::SEER Program [Medical Subject Headings] Metastasis Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] 0302 clinical medicine Surveillance Epidemiology and End Results Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Glandular and Epithelial::Carcinoma::Adenocarcinoma [Medical Subject Headings] Neoplasm Metastasis prognostic factor Metástasis neoplásica Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] Cause of death Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms [Medical Subject Headings] Hazard ratio Pronóstico General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis 030220 oncology & carcinogenesis Adenocarcinoma Original Article Female non‐small cell lung cancer Pulmonary and Respiratory Medicine medicine.medical_specialty overall survival Check Tags::Male [Medical Subject Headings] Adenocarcinoma of Lung Carcinoma de pulmón de células no pequeñas Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms [Medical Subject Headings] lcsh:RC254-282 03 medical and health sciences Internal medicine Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis [Medical Subject Headings] Adenocarcinoma del pulmón medicine metastasis Humans Lung cancer non-small cell lung cancer Aged Proportional hazards model business.industry Cancer Original Articles Anatomy::Respiratory System::Lung [Medical Subject Headings] medicine.disease 030104 developmental biology Check Tags::Female [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings] business SEER Program |
| Zdroj: | Thoracic Cancer, Vol 11, Iss 11, Pp 3357-3364 (2020) Thoracic Cancer |
| Popis: | Background Lung adenocarcinoma (ADC) is the main cause of death related to lung cancer. The aim of this study was to identify poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC in real‐world clinical practice. Methods Patients were selected from the Surveillance Epidemiology and End Results (SEER) database. Chi‐square bivariate analysis was used for the association of binary qualitative variables. A multivariate Cox regression analysis was performed to determine the impact of these prognostic factors on OS. Results A total of 46 030 patients were included (51.3% men, mean age 67.03 ± 11.6), of whom 41.3% presented with metastases in bone, 28.9% in brain, 17.1% in liver and 31.8% in lung. Patients with liver metastases presented with two or more metastatic sites more frequently than patients without liver metastases (P In this study we identified male sex, age = 65 years, lack of family support and liver and brain metastases as poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC. The presence of liver metastases emerged as the worst prognostic factor. Consequently, it should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|