Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection
Autor: | Mariza G. Morgado, Sandra W. Cardoso, Michelle Morata de Andrade, Monick Lindenmeyer Guimarães, Valdilea G. Veloso, Edson Delatorre, Diogo Gama Caetano, Ana Cristina Garcia Ferreira, Hury H. S. de Paula, Lara E. Coelho, Fernanda Heloise Côrtes, Beatriz Grinsztejn, Sylvia Lopes Maia Teixeira, Eduarda Grinsztejn João |
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Rok vydání: | 2018 |
Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Cart Adult CD4-Positive T-Lymphocytes Male medicine.medical_specialty Time Factors T cell Inflammation HIV Infections cART CD38 CD8-Positive T-Lymphocytes IP-10 Systemic inflammation Lymphocyte Activation Gastroenterology 03 medical and health sciences 0302 clinical medicine Virology Internal medicine Antiretroviral Therapy Highly Active medicine Humans 030212 general & internal medicine Immune activation business.industry Research virus diseases Middle Aged Viral Load 030104 developmental biology Infectious Diseases medicine.anatomical_structure Anti-Retroviral Agents HIV-1 acute infection Acute Disease Chronic Disease Interleukin 18 Female medicine.symptom lcsh:RC581-607 business Viral load CD8 Biomarkers IL-18 |
Zdroj: | Retrovirology Retrovirology, Vol 15, Iss 1, Pp 1-11 (2018) |
ISSN: | 1742-4690 |
Popis: | Objectives To investigate the impact of early combined antiretroviral therapy (cART) on inflammation biomarkers and immune activation during acute and early chronic HIV-1 infection. Methods We included 12 acute (AHI), 11 early chronic (EcHI), and 18 late chronic HIV-1-infected (LcHI) individuals who were treated with cART and 18 HIV-1-uninfected (HIV-neg) individuals. Plasmatic levels of inflammation biomarkers, CD8+CD38+HLA-DR+ T cell frequencies, CD4 T cell counts, CD4/CD8 ratio, total HIV-1 DNA and plasmatic viral load were evaluated. Mann–Whitney test, Pearson and Spearman correlation, and linear regression models were used for statistical analyses. Results IP-10, IL-18, and sCD163 were significantly elevated at pre-ART in the AHI and EcHI groups, showing a significant reduction after 6 months of cART in the AHI group, achieving similar levels to the HIV-neg group. For the EcHI group, the IP-10 and sCD163 levels were also significantly reduced on M6-ART; however, IP-10 levels remained higher than in the HIV-neg group, and no significant reduction of IL-18 levels was observed. The CD8+ T cell activation levels were elevated in the AHI and EcHI groups at pre-ART and showed a significant reduction on M6-ART, but they were similar to levels seen for HIV-neg only after 12 months of cART. At pre-ART, IP-10 levels but not IL-18 levels were positively correlated with HIV-1 viral load in the AHI group. Conclusions Early initiation of cART in HIV infection can reduce systemic inflammation, but the earlier normalization of the inflammation markers was only observed when cART was initiated in the acute phase of infection. A slower dynamic of reduction was observed for CD8+ T cell activation. Electronic supplementary material The online version of this article (10.1186/s12977-018-0458-6) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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