Protoparvovirus Interactions with the Cellular DNA Damage Response
| Autor: | Igor Etingov, Kinjal Majumder, David J. Pintel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
food.ingredient DNA damage lcsh:QR1-502 Mitosis Review Protoparvovirus DNA damage response Virus Replication lcsh:Microbiology Cell Line Parvovirus Mice 03 medical and health sciences Cellular DNA damage response chemistry.chemical_compound food Virology Animals Humans Cyclin B1 Animal species Cell Nucleus biology Cell Cycle Cell cycle biology.organism_classification 3. Good health Cell biology body regions 030104 developmental biology Infectious Diseases chemistry Host-Pathogen Interactions Minute Virus of Mice DNA Minute virus of mice MVM DNA Damage Signal Transduction |
| Zdroj: | Viruses Viruses, Vol 9, Iss 11, p 323 (2017) |
| ISSN: | 1999-4915 |
| Popis: | Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection. |
| Databáze: | OpenAIRE |
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