Anti-anxiety activity of successive extracts of Angelica archangelica Linn. on the elevated T-maze and forced swimming tests in rats
| Autor: | M.Y. Shah, Dinesh Kumar, Zulfiqar Ali Bhat |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Anxiolytic medicine.drug_class Ethyl acetate Angelica archangelica Antidepressant Decoction Anxiety Motor Activity chemistry.chemical_compound medicine Animals Humans Petroleum ether Rats Wistar Maze Learning Swimming Medicine(all) Traditional medicine biology business.industry Plant Extracts General Medicine T-maze biology.organism_classification Rats Elevated T-maze test chemistry Anti-Anxiety Agents Angelica archangelica linn Female business Diazepam Apiaceae medicine.drug Behavioural despair test |
| Zdroj: | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 32(3) |
| ISSN: | 0255-2922 |
| Popis: | ObjectiveAngelica archangelica Linn. is widely used in food and liquor preparations and also in Kashmiri folk medicine to reduce anxiety. We evaluated the anxiolytic effect of successive extracts of A. archangelica linn. (SAE) on rats tested in the elevated T-maze test (an animal model of generalized anxiety) at doses that exhibit antidepressant-like activity in humans.MethodsA. archangelica (1 kg) was subjected to successive extraction in a soxhlet apparatus with solvents [petroleum ether (40–60° C), chloroform, ethyl acetate, methanol and decoction with water] in order of increasing polarity (yield: 6.9%, 7.3%, 5.1%, 11.88% and 8.2% w/w, respectively). SAE were evaluated for anxiolytic effects using the elevated T-maze and forced swimming tests in rats.ResultsOral dosing of diazepam (1 mg/kg) and extracts (50, 100 and 200 mg/kg) clearly showed an anxiolytic-like profile in the elevated T-maze test: it increased one-way escape and decreased inhibitory avoidance on the first, third and seventh day. In the forced swimming test, imipramine and SAE showed antidepressant- and anxiolytic-like effects as reflected by increased climbing time, swimming time and decreased immobility time on the first, third and seventh day. Aqueous and methanol extracts showed the most, petroleum ether (40–60°C) and chloroform intermediate, and ethyl acetate the least anxiolytic activity (*P |
| Databáze: | OpenAIRE |
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