Hypomagnesemia and Cause-specific Mortality in Hemodialysis Patients: 5-year follow-up Analysis
| Autor: | Olivera Stojceva-Taneva, Goce Spasovski, Beti Zafirova-Ivanovska, Jelka Masin-Spasovska, Liljana Tozija, Zvezdana Petronijevic, Irena Rambabova-Busletic, Gjulsen Selim, Vesna Ristovska, Pavlina Dzekova-Vidimliski, Vladimir Pusevski, Ljubica Georgievska-Ismail |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty 5 year follow up medicine.medical_treatment 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering 030204 cardiovascular system & hematology Hypomagnesemia Biomaterials 03 medical and health sciences 0302 clinical medicine Renal Dialysis Risk Factors Internal medicine Natriuretic Peptide Brain Humans Medicine Magnesium Prospective Studies Renal Insufficiency Chronic Prospective cohort study Aged Proportional Hazards Models biology business.industry C-reactive protein Cause specific mortality General Medicine Middle Aged medicine.disease C-Reactive Protein Cardiovascular Diseases Multivariate Analysis biology.protein Female Hemodialysis business Follow-Up Studies |
| Zdroj: | The International Journal of Artificial Organs. 40:542-549 |
| ISSN: | 1724-6040 0391-3988 |
| Popis: | IntroductionThe aim of this prospective study was to evaluate the association between serum magnesium (Mg) and mortality, in particular the cause-specific mortality of Mg and other risk factors in hemodialysis (HD) patients.MethodsWe studied a cohort of 185 HD patients receiving thrice-weekly HD treatment, on a dialysate Mg concentration of 0.5 mmol/L. We stratified 3 patient groups according to the level of Mg: lower (1.3 mm/L).ResultsDuring the 5-year follow-up, 60 patients died, with cardiovascular (CV) disease as the predominant cause (73.3%). Hazard ratio (HR) for all-cause and CV mortality were 2.55 and 2.67 in the lower versus intermediate Mg group, but there was no significant association between the higher and intermediate Mg group. Univariate Cox regression analysis showed that Mg 1,200 pg/mL However, in the multivariate analysis only CRP ≥10 mg/L with HR 3.89 was a significant predictor of mortality. Subgroup analyses showed that among patients with CRP >10 mg/L, HR for all-cause and CV mortality of the lower versus intermediate Mg group were 1.96 and 2.39, respectively, not reaching significance for the higher versus intermediate Mg group. Conversely, there was no association between Mg level and all-cause and CV mortality within these 3 groups among patients with CRP ConclusionsLower serum Mg level was significantly associated with an increased all-cause and cardiovascular mortality in HD patients, especially in inflamed patients. |
| Databáze: | OpenAIRE |
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