Combination therapy for the treatment of neovascular age-related macular degeneration
| Autor: | Miriam Englander, Peter K. Kaiser |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Vascular Endothelial Growth Factor A
Oncology medicine.medical_specialty Combination therapy Angiogenesis medicine.medical_treatment Angiogenesis Inhibitors Photodynamic therapy Age related Internal medicine Humans Medicine Combined Modality Therapy Dosing Glucocorticoids Platelet-Derived Growth Factor Radiotherapy business.industry General Medicine Macular degeneration medicine.disease Radiation therapy Ophthalmology Photochemotherapy Wet Macular Degeneration business |
| Zdroj: | Current Opinion in Ophthalmology. 24:233-238 |
| ISSN: | 1040-8738 |
| Popis: | Purpose of review To discuss the current combination treatments that involve existing as well as novel drugs that show promise for the treatment of neovascular age-related macular degeneration. Recent findings Photodynamic therapy in combination with antivascular endothelial growth factor (VEGF) and steroids is currently used as a second-line therapy in patients not responding to monotherapy with anti-VEGF agents or in whom the treatment burden of monthly injections is too great. It is used as a primary therapy for idiopathic polypoidal choroidal vasculopathy. Radiation and antiplatelet-derived growth factor therapy show promising results and are currently under investigation. Summary Using combination treatments that target other pathways involved in angiogenesis will hopefully improve on the results of current anti-VEGF agents and may result in greater visual improvement and more convenient dosing regimens. |
| Databáze: | OpenAIRE |
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