Dependence of Urinary Prostaglandin E2 Excretion on Urinary Volume Rather than Solute Handling or Segmental Nephron Function in Man
| Autor: | Ann Burdette, William B. Campbell, S Kaojarern, D C Brater, Polavat Chennavasin |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Sodium Urinary system Indomethacin Drinking chemistry.chemical_element Nephron Urine Dinoprostone Osmolar Concentration Excretion Chlorides Furosemide Internal medicine medicine Humans Prostaglandin E2 Chemistry Prostaglandins E Nephrons General Medicine Urodynamics medicine.anatomical_structure Endocrinology Diuretic medicine.drug |
| Zdroj: | Clinical Science. 67:413-420 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs0670413 |
| Popis: | 1. Eight normal subjects underwent water loading alone and water loading plus 40 mg of frusemide IV, fluid intake ad libitum alone and fluid intake ad libitum plus frusemide, plus each of the preceding after pretreatment with indomethacin. 2. After frusemide administration, increases in urinary sodium excretion paralleled increases in urinary volume, and urinary prostaglandin E2 (PGE2) excretion correlated closely with sodium excretion (y = 1.03x −0.28; r = 0.940; P 3. In the absence of the diuretic, urinary volume varied over a wide range with little change in sodium excretion. Again, urinary PGE2 excretion correlated with urinary sodium excretion (y = 0.12x + 0.05; r = 0.789; P 4. Expressing urinary PGE2 excretion as a function of urinary volume for all of the studies resulted in a highly significant correlation (y = 10.7x −0.70; r = 0.975; P 5. Multiple and stepwise regression analyses assessing the correlation of urinary PGE2 excretion with urinary flow rate and with indices of function of various nephron segments indicate that the correlation with urinary PGE2 could be predominantly accounted for by urinary volume. 6. We conclude that in the condition of this study in man, urinary PGE2 excretion is a correlate of urinary volume. |
| Databáze: | OpenAIRE |
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