Molecular graphics applied to 5-HT3 ligands
| Autor: | S.J. Peroutka |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Models
Molecular Databases Factual Stereochemistry Computational biology Receptor binding site Molecular graphics Cellular and Molecular Neuroscience Structure-Activity Relationship Endocrinology Molecular recognition polycyclic compounds Structure–activity relationship heterocyclic compounds Computer Simulation Endocrine and Autonomic Systems Chemistry organic chemicals musculoskeletal neural and ocular physiology General Medicine Serotonin metabolism nervous system Neurology Receptors Serotonin Serotonin Antagonists Pharmacophore Chemical database |
| Zdroj: | Neuropeptides. |
| ISSN: | 0143-4179 |
| Popis: | The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer-based modelling techniques to the analysis of the 5-HT3 receptor pharmacophore. The present review summarises recent studies performed in this laboratory. The primary goal of these studies was to elucidate the chemical requirements needed for molecular recognition at the 5-HT3 receptor binding site. A secondary goal was to determine if this type of molecular information could be assessed using computerised chemical databases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|