The antigenic and immunogenic properties of synthetic peptide immunocontraceptive vaccine candidates based on gamete antigens
| Autor: | Kristen Sadler, Lorena E. Brown, Peter H. Bird, David C. Jackson |
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| Rok vydání: | 1999 |
| Předmět: |
Antigenicity
Molecular Sequence Data Epitopes T-Lymphocyte Lymphocyte Activation Epitope Mice Antigen medicine Animals Amino Acid Sequence Zona pellucida Contraception Immunologic Immunocontraception Mice Inbred BALB C Vaccines Synthetic General Veterinary General Immunology and Microbiology biology Immunogenicity Public Health Environmental and Occupational Health T helper cell Virology Infectious Diseases medicine.anatomical_structure Fertility Germ Cells Antibody Formation biology.protein Molecular Medicine Epitopes B-Lymphocyte Female Antibody |
| Zdroj: | Vaccine. 18(5-6) |
| ISSN: | 0264-410X |
| Popis: | In this study we have investigated the immunogenicity and antigenicity of synthetic immunocontraceptive vaccine candidates containing T- and B-cell epitopes arranged in different geometries. Two epitopes were selected, a B-cell epitope from fox sperm lactate dehydrogenase C(4) and a B-cell epitope from murine zona pellucida protein 3. Both were immunogenic in BALB/c mice when coupled to defined T helper cell determinants, eliciting antibodies which bound to the corresponding B-cell epitope and also to the recombinant protein. Because each of these proteins represent important components in the fertilisation process the results encourage further investigation of synthetic immunocontraceptive vaccines. |
| Databáze: | OpenAIRE |
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