A diketopiperazine dimer from a marine-derived isolate of Aspergillus niger

Autor:	Barbara M. Meurer-Grimes, Natalie Nguyen, R. Murray Tait, Howard G. Wildman, Kevin Steffy, Bin Li, Simon P. B. Ovenden, Gian Sberna, Rupal Patel
Rok vydání:	2004
Předmět:	Stereochemistry Dimer Pharmaceutical Science Diketopiperazines Piperazines Analytical Chemistry chemistry.chemical_compound Hydrolysis Coumarins Drug Discovery Organic chemistry Nuclear Magnetic Resonance Biomolecular Chromatography High Pressure Liquid Pharmacology biology Molecular Structure Chemistry Organic Chemistry Aspergillus niger Absolute configuration Australia Demethylkotanin biology.organism_classification Chiral column chromatography Complementary and alternative medicine Chromones Lactam Molecular Medicine Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Journal of natural products. 67(12)
ISSN:	0163-3864
Popis:	The new diketopiperazine dimer 1, as well as the known compounds TMC-256A1 (2), TMC-256C1 (3), and demethylkotanin (4), were isolated from a culture of Aspergillus niger. The gross structure of 1 was determined by 2D NMR studies and comparison with literature data, and the absolute stereochemistry was elucidated by chiral HPLC analysis of the hydrolysis products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a88e65aad55e1b50b635ca5600310ea https://pubmed.ncbi.nlm.nih.gov/15620260 Zobrazit plný text záznamu