Genetic variants of TAS2R38 bitter taste receptor associate with distinct gut microbiota traits in Parkinson's disease: A pilot study
| Autor: | Vanessa Palmas, Valentina Oppo, Giovanni Cossu, Daniela Perra, Sarah Vascellari, Roberto Cusano, Michele Fiorini, Melania Melis, Marta Melis, Aldo Manzin, Micaela Morelli, Iole Tomassini Barbarossa, Alessandra Serra |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Parkinson's disease Pilot Projects 02 engineering and technology Gut flora Biochemistry Receptors G-Protein-Coupled 03 medical and health sciences Immune system Clostridium Risk Factors Structural Biology Taste receptor medicine Humans Receptor Molecular Biology Aged 030304 developmental biology Genetics 0303 health sciences biology Haplotype Genetic Variation Parkinson Disease General Medicine Middle Aged 021001 nanoscience & nanotechnology biology.organism_classification medicine.disease Gastrointestinal Microbiome TAS2R38 Female 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 165:665-674 |
| ISSN: | 0141-8130 |
| Popis: | The non-tasting form of the bitter taste receptor, TAS2R38, has been shown as a genetic risk factor associated with the development of Parkinson's disease (PD). Specific taste receptors that are expressed in the lower gastrointestinal tract may respond to alteration in gut microbiota composition, detecting bacterial molecules, and regulate immune responses. Given the importance of brain-gut-microbiota axis and gene-environment interactions in PD, we investigate the associations between the genetic variants of TAS2R38 and gut microbiota composition in 39 PD patients. The results confirm that the majority of PD patients have reduced sensitivity to 6-n-propylthiouracil (PROP) and are carriers of at least one non-functional TAS2R38 AVI haplotype. Moreover, we found this correlation to be associated with a reduction in bacteria alpha-diversity with a predominant reduction of Clostridium genus. We hypothesised that the high frequency of the non-taster form of TAS2R38 associated with a diminuition of Clostridium bacteria in PD might determine a reduction in the activation of protective signalling-molecules useful in preserving gut homeostasis. This pilot study, by identifying a decrease in specific bacteria associated with a reduced sensitivity to PROP, adds essential information that opens new avenues of research into the association of PD microbiota composition and sensory modification. |
| Databáze: | OpenAIRE |
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