The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo
| Autor: | Shokhin Ie, Savchenko AIu, Volkova Ea, Ramenskaia Gv |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Taurocholic Acid
Drug media_common.quotation_subject Pharmacology Models Biological Permeability General Biochemistry Genetics and Molecular Biology Intestinal fluid Excipients Surface-Active Agents Osmotic Pressure In vivo Humans Pharmacokinetics Dissolution testing Dissolution media_common Chemistry Gastrointestinal fluids General Medicine Hydrogen-Ion Concentration Gastrointestinal Contents Gastrointestinal Tract Models Chemical Pharmaceutical Preparations Solubility Fasted state Federal state |
| Zdroj: | Biomeditsinskaya Khimiya. 57:482-489 |
| ISSN: | 2310-6905 2310-6972 |
| Popis: | The review deals with the modern tool for modeling of drug behavior in vivo, - the dissolution test in biorelevant media, imitating gastrointestinal fluids. The formulations and preparation methods of fasted state simulation intestinal fluid, FaSSIF and fed state simulation intestinal fluid, FeSSIF, are defined. In addition, the dissolution characteristics of APIs from different BCS classes in biorelevant media are described. Possible applications of biorelevant media in regulatory practice and science are also shown. |
| Databáze: | OpenAIRE |
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