A long-term study of dyslipidemia and dyslipoproteinemia in stable post-renal transplant patients
| Autor: | Andrzej Ksiazek, Elgbieta Kimak, Janusz Solski, Iwona Baranowicz-Gaszczyk |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Nephrology
Adult medicine.medical_specialty Time Factors Critical Care and Intensive Care Medicine Gastroenterology Liver disease Postoperative Complications Prednisone Diabetes mellitus Internal medicine Medicine Humans Longitudinal Studies Dyslipidemias Kidney business.industry General Medicine Middle Aged medicine.disease Kidney Transplantation Lipids Transplantation Endocrinology medicine.anatomical_structure lipids (amino acids peptides and proteins) Poland business Dyslipidemia medicine.drug Lipoprotein |
| Zdroj: | Renal failure. 28(6) |
| ISSN: | 0886-022X |
| Popis: | Dyslipidemia is a major risk factor for atherosclerotic disease in renal transplant patients.The serum levels of lipids and lipoproteins were determined in the same 12 post-renal transplant patients (TX) 10-29 and 73-122 months after transplantation. Thirteen healthy subjects--i.e., without diabetes, endocrine disease, liver disease, active inflammatory disease, glucose intolerance, malignancy, obesity, and urinary protein--were used as a reference group. TX patients had stable renal function. Twelve patients received cyclosporine A and prednisone, six received lovastatin, and one received rapa and prednisone. Lipids and lipoprotein (apo)AI and B were determined using Roche kits. An anti-apoB antibody was used to separate apoB-containing apoCIII and apoE lipoproteins as triglyceride-rich lipoproteins (TRLs) in the non-HDL fraction from apoCIIInonB and apoEnonB in the HDL fraction.In both groups of post-renal transplant patients, a statistically significant increase of TG, TC, and non-HDL-C levels was observed. Moreover, statistically significant changes were shown in total apoCIII and apoCIIInonB, as well as in TG/HDL-C and apoAI/apoCIII ratios, as compared to the reference group. On the other hand, in TX patients 73-122 months after transplantation, significantly higher concentrations of TC, LDL-C, and especially non-HDL-C were observed. It was shown that apoCIII, apoCIIInonB, apoB:CIII, and lipid and lipoprotein ratios as risk factors of atherosclerosis and renal risk factors were higher in these patients 73-122 months after transplantation.TX patients in a long-term study showed that they had disturbed lipoprotein composition, and its consequence was hyperlipidemia, perhaps partly due to the increased use of immunosuppressants and steroids. |
| Databáze: | OpenAIRE |
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