A new Escherichia coli cell division gene, ftsK
| Autor: | S J Dewar, K J Begg, William D. Donachie |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cell division
Molecular Sequence Data Peptidoglycan Muramoylpentapeptide Carboxypeptidase Biology medicine.disease_cause Microbiology Protein Structure Secondary chemistry.chemical_compound Suppression Genetic Plasmid Bacterial Proteins Consensus Sequence Escherichia coli medicine Consensus sequence Penicillin-Binding Proteins Amino Acid Sequence Molecular Biology Peptide sequence Gene Recombination Genetic Genetics Mutation Binding Sites Base Sequence Sequence Homology Amino Acid Escherichia coli Proteins Genetic Complementation Test fungi Chromosome Mapping Membrane Proteins Sequence Analysis DNA Phenotype Hexosyltransferases chemistry Genes Bacterial Peptidyl Transferases Carrier Proteins Cell Division DNA Research Article |
| Zdroj: | Journal of Bacteriology. 177:6211-6222 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.177.21.6211-6222.1995 |
| Popis: | A mutation in a newly discovered Escherichia coli cell division gene, ftsK, causes a temperature-sensitive late-stage block in division but does not affect chromosome replication or segregation. This defect is specifically suppressed by deletion of dacA, coding for the peptidoglycan DD-carboxypeptidase, PBP 5. FtsK is a large polypeptide (147 kDa) consisting of an N-terminal domain with several predicted membrane-spanning regions, a proline-glutamine-rich domain, and a C-terminal domain with a nucleotide-binding consensus sequence. FtsK has extensive sequence identity with a family of proteins from a wide variety of prokaryotes and plasmids. The plasmid proteins are required for intercellular DNA transfer, and one of the bacterial proteins (the SpoIIIE protein of Bacillus subtilis) has also been implicated in intracellular chromosomal DNA transfer. |
| Databáze: | OpenAIRE |
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