Investigation of the Relationship between the Mid_Thigh Adipose Tissue Distribution Measured by MRI and Serum Osteocalcin—A Sex-Based Approach
| Autor: | Eva Hassler, Gunter Almer, Gernot Reishofer, Hannes Deutschmann, Wilfried Renner, Markus Herrmann, Stefan Leber, Alexander Staszewski, Felix Gunzer, Harald Mangge |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male subcutaneous adipose tissue insulin Nutrition and Dietetics Nutrition. Foods and food supply glucose metabolism Osteocalcin Middle Aged Magnetic Resonance Imaging Article intramuscular adipose tissue Sex Factors Adipose Tissue osteocalcin Body Composition Humans TX341-641 Female Food Science |
| Zdroj: | Nutrients Nutrients; Volume 14; Issue 1; Pages: 112 Nutrients, Vol 14, Iss 112, p 112 (2022) |
| ISSN: | 2072-6643 |
| Popis: | Osteocalcin, in its non-carboxylated form, has a positive effect on glucose metabolism. Additionally, osteocalcin levels are related to body composition, especially muscle mass. The relation to the distribution of different adipose tissue types, such as subcutaneous, intermuscular, and visceral adipose tissue, is unclear. This study aimed to investigate associations between serum osteocalcin and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh. Furthermore, the influence of different training methods on osteocalcin levels was investigated. We performed adipose tissue quantification of subcutaneous adipose tissue (SAT) and intramuscular adipose tissue (IMAT) using MRI measurements of the mid-thigh in 128 volunteers (63 male/65 female). Laboratory analysis included blood lipid panel, serum insulin, adiponectin, and osteocalcin measurements. The main observation was a significant correlation of total serum osteocalcin (TOC) and the distribution of adipose tissue of the mid-thigh (SAT/(SAT + IMAT)) (cc = −0.29/p-value = 0.002), as well as the cross-sectional muscle area (MA), increasing with the weekly resistance training duration in males. Additionally, TOC (p-value = 0.01) and MA (p-value = 0.03) were negatively related to serum insulin. The significant relationship between TOC and SAT/(SAT + IMAT) is a new finding and confirms the negative influence of IMAT on glucose metabolism in a sex-specific approach. We could substantiate this by the negative relation of TOC with serum insulin. |
| Databáze: | OpenAIRE |
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