Paediatric systemic lupus erythematosus: A single referral centre experience
| Autor: | Fatih Sap, Mustafa Bulut, Necdet Poyraz, Fatih Akin, Bülent Ataş, Abdullah Yazar, Hüseyin Tokgöz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Anti-nuclear antibody Lupus nephritis Internal medicine medicine Complement 3 Humans Lupus Erythematosus Systemic Age of Onset Child Referral and Consultation biology business.industry General Medicine medicine.disease Lupus Nephritis Joint involvement Antibodies Antinuclear Referral centre Joint problems biology.protein Female Antibody medicine.symptom business Malar rash |
| Zdroj: | JPMA. The Journal of the Pakistan Medical Association. 71(1(A)) |
| ISSN: | 0030-9982 |
| Popis: | In this study, the clinical and laboratory findings, management and follow-up of 32 children with paediatric systemic lupus erythematosus (pSLE) were evaluated to determine the prognostic factors in pSLE. Of the 32 patients, 25 (78.1%) were females. Age at onset of symptoms and diagnosis in the patients were 147.6 ± 49 months and 154.3 ± 48 months, respectively. The most common symptom on admission were joint problems, seen in 25 (78.1%) patients. Haematological alterations were seen in 25 (78.1%) cases during follow-up. Lupus nephritis was diagnosed in 10 (31.2%) patients. Malar rash was seen in a total of 12 (37.5%) patients during follow up, however it had been noted in five (15.6%) patients on admission. Antinuclear antibody and anti-dsDNA were positive in all patients and 31 (96.8%) patients, respectively. Decreased complement 3 and 4 levels were noted in 23 (71.8%) patients. Antiphospholipid antibody was studied in 27 patients and it was found to be positive in 13 (48.1%) patients. In conclusion, based on our findings, we would like to emphasize that pSLE has a large and remarkable clinical and laboratory findings. |
| Databáze: | OpenAIRE |
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