Bone regeneration and infiltration of an anisotropic composite scaffold: an experimental study of rabbit cranial defect repair
| Autor: | Yi Man, Yili Qu, Jidong Li, Fu You, Qin Zou, Jiaxing Jiang, Yubao Li, Yi Zuo, Limei Li, Minpeng Lu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cranial defect Scaffold Bone Regeneration Materials science Biomedical Engineering Biophysics Biocompatible Materials Bioengineering 02 engineering and technology Bone tissue Interconnectivity Biomaterials 03 medical and health sciences Osteogenesis medicine Animals Composite scaffold Composite material Anisotropy Bone regeneration Cell Proliferation Tissue Scaffolds Skull 021001 nanoscience & nanotechnology medicine.disease Rats Nylons Durapatite 030104 developmental biology medicine.anatomical_structure Rabbits 0210 nano-technology Porosity Infiltration (medical) Biomedical engineering |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 27:327-338 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1080/09205063.2015.1128248 |
| Popis: | Tissue formation on scaffold outer edges after implantation may restrict cell infiltration and mass transfer to/from the scaffold center due to insufficient interconnectivity, leading to incidence of a necrotic core. Herein, a nano-hydroxyapatite/polyamide66 (n-HA/PA66) anisotropic scaffold with axially aligned channels was prepared with the aim to enhance pore interconnectivity. Bone tissue regeneration and infiltration inside of scaffold were assessed by rabbit cranial defect repair experiments. The amount of newly formed bone inside of anisotropic scaffold was much higher than isotropic scaffold, e.g., after 12 weeks, the new bone volume in the inner pores was greater in the anisotropic scaffolds (>50%) than the isotropic scaffolds ( |
| Databáze: | OpenAIRE |
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