Ecomycins, unique antimycotics from Pseudomonas viridiflava
| Autor: | D B Teplow, D Garton-Kenny, Margaret M. Condron, J Sears, C M Miller, B Redgrave, Gary A. Strobel, R V Miller |
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| Rok vydání: | 1998 |
| Předmět: |
Antifungal Agents
Magnetic Resonance Spectroscopy Homoserine Microbial Sensitivity Tests Microbiology Applied Microbiology and Biotechnology Mass Spectrometry Minimum inhibitory concentration chemistry.chemical_compound Pseudomonas Humans Amino Acids Threonine Chromatography High Pressure Liquid chemistry.chemical_classification Chromatography biology Pseudomonas viridiflava Fungi General Medicine Hydrogen-Ion Concentration biology.organism_classification Anti-Bacterial Agents Amino acid Molecular Weight Solubility Biochemistry chemistry High Pressure Liquid Glycine Solvents Intercellular Signaling Peptides and Proteins Peptides Oligopeptides Biotechnology Pseudomonadaceae |
| Zdroj: | Miller, CM; Miller, RV; Garton-Kenny, D; Redgrave, B; Sears, J; Condron, MM; et al.(1998). Ecomycins, unique antimycotics from Pseudomonas viridiflava. Journal of Applied Microbiology, 84(6), 937-944. doi: 10.1046/j.1365-2672.1998.00415.x. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7k1710mw Journal of applied microbiology, vol 84, iss 6 |
| ISSN: | 1365-2672 1364-5072 |
| DOI: | 10.1046/j.1365-2672.1998.00415.x |
| Popis: | A novel family of peptide antimycotics, termed ecomycins, is described from Pseudomonas viridiflava, a plant-associated bacterium. Ecomycins B and C have molecular masses of 1153 and 1181. They contain equimolar amounts of a beta hydroxyaspartic acid, homoserine, threonine, serine, alanine, glycine and one unknown amino acid. Fatty acids were detectable after hydrolysis, methylation and gas chromatography and mass spectroscopy. The ecomycins have significant bioactivities against a wide range of human and plant pathogenic fungi. The minimum inhibitory concentration values for ecomycin B were 4.0 micrograms ml-1 against Cryptococcus neoformans and 31 micrograms ml-1 against Candida albicans. Pseudomonas viridiflava also produces what appears to be syringotoxin, an antifungal lipopeptide previously described from Ps. syringae. |
| Databáze: | OpenAIRE |
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