Magnolol inhibits cancer stemness and IL-6/Stat3 signaling in oral carcinomas
| Autor: | Cheng-Chia Yu, Chun-Chung Huang, Yi-Wen Liao, Pei Ming Chu, Shih-Shen Lin, Pei-Ling Hsieh, Chuan-Hang Yu, Chih-Yu Peng |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
STAT3 Transcription Factor
Medicine (General) Cell medicine.disease_cause Lignans Metastasis 03 medical and health sciences chemistry.chemical_compound R5-920 0302 clinical medicine Cancer stem cell Cell Line Tumor medicine Humans Cytotoxicity Cisplatin Oral squamous cell carcinomas biology Cancer stem cells Interleukin-6 Squamous Cell Carcinoma of Head and Neck business.industry Biphenyl Compounds General Medicine biology.organism_classification medicine.disease Magnolol stomatognathic diseases Magnolia officinalis medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Cancer research 030211 gastroenterology & hepatology Carcinogenesis business medicine.drug |
| Zdroj: | Journal of the Formosan Medical Association, Vol 121, Iss 1, Pp 51-57 (2022) |
| ISSN: | 0929-6646 |
| DOI: | 10.1016/j.jfma.2021.01.009 |
| Popis: | Background/purpose Cancer stem cells (CSCs) have been known to be implicated in tumorigenesis, metastasis, and drug resistance in oral squamous cell carcinomas (OSCC). In this study, we aimed to investigate whether magnolol, a polyphenolic component derived from Magnolia officinalis, exhibited the anti-CSCs properties. Methods The cytotoxicity of magnolol was tested using normal gingival epithelioid SG cells and sphere-forming OSCC-CSCs isolated from SAS, OECM1, and GNM cells. Secondary sphere-forming ability, the proportion of ALDH1 positive cells, Transwell migration, and invasion capacities were examined as well. The chemosensitive effects of magnolol were investigated using MTT, secondary sphere-forming, and invasion assays. Results Magnolol exerted a higher cytotoxicity of OSCC-CSCs and cancer stemness features, including self-renewal ability, the expression CSC marker, migration, and invasion capacities were all downregulated in magnolol-treated OSCC-CSCs. Moreover, administration of magnolol potentiated the effect of cisplatin, including a decrease in cell viability, self-renewal, and invasion activities. In addition, we observed that the secretion of IL-6 and phosphorylation of Stat3 were decreased in OSCC-CSCs treated with magnolol. Conclusion Our data suggest that magnolol is able to target CSCs and suppress the cancer stemness properties, at least in part, via IL-6/Stat3 signaling. Besides, a dietary supplement of magnolol may function as an adjunct to cisplatin treatment. |
| Databáze: | OpenAIRE |
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