Subacute toxicity of ethylenebisisothiocyanate sulfide in the laboratory rat
| Autor: | Ronald L. Persing, Ronald L. Baron, Gail A. Kerchner, Irwin Baumel, Ralph I. Freudenthal |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Dermatitis Thyroid Function Tests Toxicology Thyroid function tests Lesion Iodine Radioisotopes Isothiocyanates Internal medicine Paralysis medicine Ingestion Animals Triiodothyronine Methimazole medicine.diagnostic_test Dose-Response Relationship Drug business.industry Thyroid Body Weight Organ Size Triazoles Pollution Laboratory rat Diet Rats Thyroxine Endocrinology medicine.anatomical_structure medicine.symptom Thyroid function business Thiocyanates |
| Zdroj: | Journal of toxicology and environmental health. 2(5) |
| ISSN: | 0098-4108 |
| Popis: | Ethylenebisisothiocyanate sulfide (EBIS) was administered in the diet to groups of rats at 0, 1, 10, 100, and 1,000 ppm for up to 90 days. The rats receiving EBIS at 1,000 ppm demonstrated a toxic response within 8–14 days, reflected as a reversible paralysis of the hind legs. If left on the 1,000 ppm diet, the animals soon died. When removed from the diet, the animals recovered, only to become atoxic on further dietary exposure at the high level. No histologic lesion could be identified in either H&E‐ or luxol fast blue‐stained sections of brain, spinal cord, or peripheral nerves from the paralyzed animals. The ability to reverse the paralysis by removing the animals from the test diet coupled with the lack of histologically observable lesions suggests a biochemical (reversible) rather than somatic lesion. Ingestion of 1,000 ppm EBIS for 7 days resulted in measurable changes in thyroid function. Total serum thyroxine levels were markedly decreased, as was iodide uptake by the thyroid. Ingestion of EBIS a... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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