Alterations of synaptic plasticity in aged rats: Evidence of functional and morphological studies

Autor:	Jie Ren, Jing Jia, Xin-xing Fang, Qiong Xiang, Yu-chun Dong, Cheng Ou-Yang, Xian-Hui Li
Rok vydání:	2018
Předmět:	Male 0301 basic medicine Aging Synaptophysin Biomedical Engineering Biophysics Health Informatics Bioengineering Disease Hippocampal formation Biology Hippocampus Rats Sprague-Dawley Biomaterials 03 medical and health sciences 0302 clinical medicine Western blot Memory Memory improvement medicine Animals Cognitive decline Memory Disorders Neuronal Plasticity medicine.diagnostic_test Cognition Rats 030104 developmental biology Synaptic plasticity biology.protein Cognition Disorders Neuroscience 030217 neurology & neurosurgery Information Systems
Zdroj:	Technology and Health Care. 26:271-278
ISSN:	1878-7401 0928-7329
Popis:	Background The aging-related disease and associated neurodegenerative complications, such as cognitive impairment, has received increasing attention. Objective The aim of this study was to show changes in cognitive behavior and molecular related the synaptic plasticity in aged-induced cognitive deficits rats. Methods We used novel object recognition testing and morphological staining as well as western blot to detect changes in cognitive behavior and molecular related the synaptic plasticity. Results The morphological changes of synaptic structure and number on hippocampal neurons and learning and memory deficits were shown during natural aging. Moreover, learning and memory improvement was associated with alterations of hippocampal synaptic plasticity-related proteins, such as SNAP-25, synaptophysin, snapsoin-1 and so on, which distributes to cognitive decline in natural aging. Conclusions Our study provides more behavior and molecular evidence on relationship of cognitive deficits and aging.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a78a5e33be3571b32cddab37dfcab54 https://doi.org/10.3233/thc-170978 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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