ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus
| Autor: | Chen-Ming Fan, Bernadette C. Holdener, Jacques L. Michaud, Charles DeRossi, Noah R. May |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
endocrine system
medicine.medical_specialty Embryology Aryl hydrocarbon receptor nuclear translocator Hypothalamus Midline Thalamic Nuclei Gene Expression Biology Supraoptic nucleus Mice Internal medicine medicine Basic Helix-Loop-Helix Transcription Factors Animals Secretion Transcription factor Neuroendocrine cell digestive oral and skin physiology Aryl Hydrocarbon Receptor Nuclear Translocator Helix-Loop-Helix Motifs ARNTL Transcription Factors Cell biology DNA-Binding Proteins Mice Inbred C57BL Repressor Proteins Endocrinology medicine.anatomical_structure nervous system Receptors Aryl Hydrocarbon SIM1 Dimerization Supraoptic Nucleus hormones hormone substitutes and hormone antagonists Homeostasis Transcription Factors Developmental Biology |
| Zdroj: | Mechanisms of Development. 90(2):253-261 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(99)00328-7 |
| Popis: | One major function of the hypothalamus is to maintain homeostasis by modulating the secretion of pituitary hormones. The paraventricular (PVN) and supraoptic (SON) nuclei are major integration centers for the output of the hypothalamus to the pituitary. The bHLH–PAS transcription factor SIM1 is crucial for the development of several neuroendocrine lineages within the PVN and SON. bHLH–PAS proteins require heterodimerization for their function. ARNT, ARNT2, and BMAL1 are the three known general heterodimerization partners for bHLH–PAS proteins. Here, we provide evidence that Sim1 and Arnt2 form dimers in vitro, that they are co-expressed in the PVN and SON, and that their loss of function affects the development of the same sets of neuroendocrine cell types within the PVN and SON. Together, these results implicate ARNT2 as the in vivo dimerization partner of SIM1 in controlling the development of these neuroendocrine lineages. |
| Databáze: | OpenAIRE |
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