Synthesis, antioxidant and antimicrobial activity of carbohydrazones
| Autor: | Irena Novaković, Jasmina B. Nikolić, Aleksandar D. Marinković, Saša Ž. Drmanić, Aleksandra R. Božić, Snežana Bjelogrlić, Nenad Filipovic |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Antifungal
Antioxidant medicine.drug_class medicine.medical_treatment antioxidant activity 010402 general chemistry 01 natural sciences lcsh:Chemistry medicine Molecule Organic chemistry biology 010405 organic chemistry Chemistry General Chemistry Antimicrobial biology.organism_classification In vitro carbohydrazones 0104 chemical sciences antibacterial lcsh:QD1-999 isomers Compound A4 Isomerization Bacteria antifungal |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 82, Iss 5, Pp 495-508 (2017) Journal of the Serbian Chemical Society JOURNAL OF THE SERBIAN CHEMICAL SOCIETY |
| ISSN: | 1820-7421 0352-5139 |
| Popis: | Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide–water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172013] |
| Databáze: | OpenAIRE |
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