Early Effect of 0.005% Estriol Vaginal Gel on Symptoms and Signs of Vulvovaginal Atrophy
| Autor: | Jesús Lázaro-Carrasco de la Fuente, Marcos Cuerva González, Silvia González Rodríguez, Juan Luis Delgado Marín, Carmen Cuevas Castillo, Concepción Nieto Magro |
|---|---|
| Rok vydání: | 2022 |
| Zdroj: | Journal of Menopausal Medicine. 28:60 |
| ISSN: | 2288-6761 2288-6478 |
| Popis: | This study aims to assess the effect of ultralow dose 0.005% estriol vaginal gel in women with genitourinary syndrome of menopause (GSM).In this prospective and multicenter single-arm study, efficacy was assessed by the evaluation of the epithelial maturation value (MV), vaginal pH, symptoms and signs of vulvovaginal atrophy. Tolerability, acceptability, and the effect on intimate relationships were also evaluated.We included 35 postmenopausal women with moderate-to-severe vaginal dryness. The most bothering symptom reported was vaginal dryness. The mean increase in the MV after 7 and 14 days of treatment were 22.1 (Ultralow dose 0.005% estriol vaginal gel produced a rapid improvement of most relevant symptoms and signs of GSM. This clinically meaningful response was observed from the initial days of treatment, confirming a fast onset and a progressive action. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|