Role of ion channels in coronary microcirculation: a review of the literature
| Autor: | Francesco Fedele, Rocco Stio, Alessandra D'Ambrosi, Bruno Brasolin, Massimo Mancone, Noemi Bruno, Carmen Caira, Vahagn Ohanyan, Paolo Severino |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle Endothelium Vasodilation Context (language use) Ion Channels Muscle Smooth Vascular Coronary Circulation Internal medicine medicine Animals Humans Endothelial dysfunction Ion channel business.industry Microcirculation Blood flow medicine.disease Coronary Vessels medicine.anatomical_structure Cardiology Molecular Medicine Endothelium Vascular Cardiology and Cardiovascular Medicine business Homeostasis |
| Zdroj: | Future Cardiology. 9:897-905 |
| ISSN: | 1744-8298 1479-6678 |
| Popis: | In normal coronary arteries, several different mechanisms of blood flow regulation exist, acting at different levels of the coronary tree: endothelial, nervous, myogenic and metabolic regulation. In addition, physiologic blood flow regulation is also dependent on the activity of several coronary ion channels, including ATP-dependent K+ channels, voltage-gated K+ channels and others. In this context, ion channels contribute by matching demands for homeostatic maintenance. They play a primary role in rapid response of both endothelium and vascular smooth muscle cells of larger and smaller arterial vessels of the coronary bed, leading to coronary vasodilation. Consequently, an alteration in ion channel function or expression could be directly involved in coronary vasomotion dysfunction. |
| Databáze: | OpenAIRE |
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