Influence of particle size on the adsorption and release of cephalexin encapsulated in mesoporous silica SBA-15
| Autor: | Elena Isabel Basaldella, María Soledad Legnoverde |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Sba-15 Otras Ingeniería de los Materiales INGENIERÍAS Y TECNOLOGÍAS 02 engineering and technology 010402 general chemistry 01 natural sciences Adsorption Ingeniería de los Materiales General Materials Science Cephalexin Chromatography Mechanical Engineering Particle size Mesoporous silica 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Chemical engineering Mechanics of Materials Agglomerate Drug delivery Particle 0210 nano-technology Mesoporous material Drug carrier |
| Zdroj: | Materials Letters. 181:331-334 |
| ISSN: | 0167-577X |
| DOI: | 10.1016/j.matlet.2016.06.053 |
| Popis: | Ordered mesoporous silicas with different particle sizes were synthesized and used as drug carrier in controlled delivery systems. Morphological properties of mesoporous supports were modified by changing the stirring rate. Changes in the shape of SBA-15 from fiber-like particles to smaller irregular agglomerates were obtained by reducing the stirring rate. The adsorption and release of cephalexin from those different supports were investigated. Adsorption capacity was found to increase with decreasing particle sizes, and the in vitro release experiments indicated a clear increase in the amount released from the smaller particles. In vivo studies revealed that silica matrixes effectively control the drug release and were capable of maintaining a sustained therapeutic blood level of cephalexin. Fil: Legnoverde, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas ; Argentina Fil: Basaldella, Elena Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas ; Argentina |
| Databáze: | OpenAIRE |
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