Evaluation of a commercially available hyperimmune plasma product for prevention of naturally acquired pneumonia caused by Rhodococcus equi in foals
| Autor: | Corey Miller, Steeve Giguère, Gaskin Jm, James L. Bowman |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
animal diseases Population Enzyme-Linked Immunosorbent Assay digestive system Gastroenterology Rhodococcus equi Immunity Internal medicine biology.animal parasitic diseases Pneumonia Bacterial Animals Medicine Clinical significance Horses education education.field_of_study General Veterinary biology business.industry Incidence (epidemiology) Immunization Passive biology.organism_classification medicine.disease Antibodies Bacterial Pneumonia Foal Immunology biology.protein Horse Diseases Antibody business Actinomycetales Infections Immunity Maternally-Acquired |
| Zdroj: | Journal of the American Veterinary Medical Association. 220:59-63 |
| ISSN: | 0003-1488 |
| DOI: | 10.2460/javma.2002.220.59 |
| Popis: | Objective—To determine efficacy of a commercially available hyperimmune plasma product for prevention of naturally acquired pneumonia caused by Rhodococcus equiin foals. Design—Randomized clinical trial. Animals—165 foals. Procedure—Foals were randomly assigned to 1 of 2 groups (hyperimmune plasma or nontreated controls). Foals with failure of passive transfer (FPT) of immunity were treated with hyperimmune plasma and evaluated as a third group. Foals that received plasma were given 950 ml between 1 and 10 days of age and between 30 and 50 days of age. A tracheobronchial aspirate was obtained from foals with clinical signs of respiratory tract disease for bacteriologic culture. Results—A significant difference in incidence of pneumonia caused by R equi in foals with adequate passive transfer was not detected between foals that received plasma (19.1%) and nontreated foals (30%). Of 13 foals without FPT that received plasma and developed pneumonia caused by R equi, 12 developed disease prior to administration of the second dose of hyperimmune plasma. Incidence of undifferentiated pneumonia of all causes was not different between groups. Conclusion and Clinical Relevance—Intravenous administration of the commercially available hyperimmune plasma was safe, and the product contained high concentrations of anti-R equi antibodies. However, within this limited foal population, the difference in incidence of pneumonia caused by R equi observed between foals that received plasma and control foals was not significant. (J Am Vet Med Assoc 2002;220:59–63) |
| Databáze: | OpenAIRE |
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