Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health
| Autor: | Charles Sultan, Marie-Odile Soyer-Gobillard, Laura Gaspari, Nicolas Kalfa, Françoise Paris, Samir Hamamah |
|---|---|
| Přispěvatelé: | Gaspari, Laura, Développement Embryonnaire, Fertilité et Environnement (DEFE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Sorbonne Université (SU), CHU Montpellier, Hôpital Lapeyronie [Montpellier] (CHU), Unité d'AMP/DPI, Département de Médecine et biologie de la reproduction, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Polychlorinated Dibenzodioxins
Physiology Review MESH: Reproduction chemistry.chemical_compound 0302 clinical medicine [CHIM] Chemical Sciences Biology (General) Spectroscopy media_common Reproductive health MESH: Polychlorinated Dibenzodioxins 0303 health sciences 030219 obstetrics & reproductive medicine Reproduction Epigenetic General Medicine MESH: Reproductive Health 3. Good health Computer Science Applications Chemistry Reproductive Health Human reproductive system Endocrine disruptors (EDs) MESH: AnimaLs QH301-705.5 media_common.quotation_subject MESH: Environmental Exposure Fertility Biology Murine models dioxin (TCDD) Hazardous Substances Catalysis [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction Inorganic Chemistry 03 medical and health sciences Transgenerational epigenetics medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Animals Humans Endocrine system [CHIM]Chemical Sciences [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Epigenetics Physical and Theoretical Chemistry Molecular Biology QD1-999 030304 developmental biology Pregnancy MESH: Humans business.industry Organic Chemistry Environmental Exposure medicine.disease Multigenerational transmission MESH: Hazardous Substances chemistry Effects on dioxin (TCDD) business Toxicant |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, 2021, 22 (16), pp.9091. ⟨10.3390/ijms22169091⟩ International Journal of Molecular Sciences, Vol 22, Iss 9091, p 9091 (2021) International Journal of Molecular Sciences, MDPI, 2021, 22 (16), pp.9091. ⟨10.3390/ijms22169091⟩ |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | International audience; Previous studies have demonstrated that endocrine disruptors (EDs) can promote the transgenerational inheritance of disease susceptibility. Among the many existing EDs, 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) affects reproductive health, including in humans, following direct occupational exposure or environmental disasters, for instance the Agent Orange sprayed during the Vietnam War. Conversely, few studies have focused on TCDD multigenerational and transgenerational effects on human reproductive health, despite the high amount of evidence in animal models of such effects on male and female reproductive health that mimic human reproductive system disorders. Importantly, these studies show that paternal ancestral TCDD exposure substantially contributes to pregnancy outcome and fetal health, although pregnancy outcome is considered tightly related to the woman’s health. In this work, we conducted a systematic review of the literature and a knowledge synthesis in order (i) to describe the findings obtained in rodent models concerning TCDD transgenerational effects on reproductive health and (ii) to discuss the epigenetic molecular alterations that might be involved in this process. As ancestral toxicant exposure cannot be changed in humans, identifying the crucial reproductive functions that are negatively affected by such exposure may help clinicians to preserve male and female fertility and to avoid adverse pregnancy outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|