Putative loss of CD83 immunosuppressive activity in long-standing complication-free juvenile diabetic patients during disease progression
| Autor: | Urszula Ławrynowicz, Ulana Juhas, Jolanta Myśliwska, Monika Ryba-Stanisławowska, Małgorzata Myśliwiec |
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| Rok vydání: | 2019 |
| Předmět: |
Male
musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Adolescent Immunology Immunoglobulins Stimulation Dendritic cell differentiation Antigens CD Internal medicine Diabetes mellitus medicine Humans Child Cells Cultured Glycated Hemoglobin Immunosuppression Therapy Type 1 diabetes Membrane Glycoproteins Tumor Necrosis Factor-alpha business.industry Monocyte Cell Differentiation Dendritic Cells medicine.disease Diabetes Mellitus Type 1 Endocrinology medicine.anatomical_structure Gene Expression Regulation Monocyte differentiation Metabolic control analysis Disease Progression Female Tumor necrosis factor alpha business |
| Zdroj: | Immunologic Research. 67:70-76 |
| ISSN: | 1559-0755 0257-277X |
| DOI: | 10.1007/s12026-019-09074-y |
| Popis: | The CD83 molecule is a known marker of dendritic cell differentiation process, and its soluble form (sCD83) exerts immunosuppressive functions. In our research, we examined whether the sCD83 plasma concentration is impaired in DM1 children and if the expected changes are in line with the disturbed process of monocyte’s transformation into mCD83+ monocyte-derived cells. 28 newly diagnosed (ND-DM1) and 30 long-standing (LS-DM1) patients were enrolled into our study. We revealed that the examined cells show a high mCD83 expression level in ND-DM1, which was significantly downregulated by the TNF-α stimulation. The results were in line with those from healthy controls. We also observed that monocyte differentiation process into CD83+ cells was much defective in LS-DM1 children and the mCD83 expression level seems not to be controlled by TNF-α. Moreover, the sCD83 level was significantly decreased in plasma from LS-DM1 children and it was negatively related to HbA1c levels, while no correlations were observed between TNF-α plasma concentration or disease duration. Summarizing, our results suggest that reduced sCD83 levels may correspond with a poor metabolic control in LS-DM1 patients and therapeutic administration of this molecule may indicate a new therapy approach in the chronic phase of diabetes. |
| Databáze: | OpenAIRE |
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