Recycling probability and dynamical properties of germinal center reactions
| Autor: | Andreas Deutsch, Michael Meyer-Hermann, Michal Or-Guil |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Statistics and Probability
Plasma Cells FOS: Physical sciences Lymphocyte Activation General Biochemistry Genetics and Molecular Biology Antibodies Cell Behavior (q-bio.CB) Centroblasts Animals Point Mutation Physics - Biological Physics Antigens Antibody types Probability Genetics Physics B-Lymphocytes General Immunology and Microbiology Applied Mathematics Models Immunological Germinal center Cell Differentiation General Medicine Dendritic Cells Germinal Center Cell biology Shape space Biological Physics (physics.bio-ph) FOS: Biological sciences Modeling and Simulation Quantitative Biology - Cell Behavior General Agricultural and Biological Sciences Cell Division |
| Zdroj: | Journal of theoretical biology. 210(3) |
| ISSN: | 0022-5193 |
| Popis: | We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to centroblasts. We use exclusively parameters with a direct biological interpretation such that, once determined by experimental data, the model gains predictive power. Based on the experiment of Han et al. (1995b) we predict that a high rate of recycling of centrocytes to centroblasts is necessary for the germinal center reaction to work reliably. Furthermore, we find a delayed start of the production of plasma and memory cells with respect to the start of point mutations, which turns out to be necessary for the optimization process during the germinal center reaction. The dependence of the germinal center reaction on the recycling probability is analyzed. Comment: 30 pages, 8 figures |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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