Synthesis of AMPSA Polymeric Derivatives Monitored by Electrical Conductivity and Evaluation of Thermosensitive Properties of Resulting Microspheres
| Autor: | Magdalena Sacharczuk, Witold Musiał, Agnieszka A. Gola |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Alkanesulfonates
N-isopropylacrylamide Polymers Dispersity Acrylic Resins Pharmaceutical Science Article Phase Transition Polymerization Analytical Chemistry lcsh:QD241-441 cationic initiator Dynamic light scattering lcsh:Organic chemistry Drug Discovery Zeta potential Humans Particle Size Physical and Theoretical Chemistry volume phase transition temperature chemistry.chemical_classification microparticles Acrylamides Drug Carriers Chemistry Organic Chemistry Electric Conductivity Temperature Cationic polymerization 2-acrylamido-2-methyl-1-propanesulfonic acid Polymer conductivity measurements Microspheres Chemistry (miscellaneous) Precipitation polymerization Molecular Medicine Particle size Sulfonic Acids Nuclear chemistry |
| Zdroj: | Molecules, Vol 24, Iss 6, p 1164 (2019) Molecules Volume 24 Issue 6 |
| ISSN: | 1420-3049 |
| Popis: | Four stimuli-responsive polymers of N-isopropylacrylamide (NIPA) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPSA) and crosslinked derivatives by N,N&prime methylene bisacrylamide (MBA) were synthesized: PNA, PAMPSA, PNAM, PAMPSAM. The effect of the cross-linker and methyl sulphonic acid (-CH3-SO3H) group on particle size, aggregation and volume phase transition temperature (VPTT) was investigated. Polymeric particles were synthesized via the surfactant free precipitation polymerization (SFPP) at 70 ° C in the presence of cationic initiator 2,2&prime azobis[2-methylpropionamidine] dihydrochloride (AMP) system. Chemical composition and morphology of investigated samples were evaluated using ATR-FTIR spectroscopy, 1H-NMR spectrometry and SEM-EDS techniques. The hydrodynamic diameters (HD), zeta potential (ZP), and polydispersity index (PDI) in aqueous dispersions were assessed by dynamic light scattering (DLS) between 18&ndash 42 ° C. HD values at 18 ° C for PNA, PAMPSA, PNAM, PAMPSAM polymers were approx. 32, 730, 715, 665 nm, and ZP values were &minus 1.36, &minus 0.01, 8.90, &minus 0.09 mV, respectively. The VPTT range was observed between 29 and 41 ° C. PDI&rsquo s for PNA and PNAM were low and varied between 0.276 and 0.460, and between 0.119 and 0.056, respectively. PAMPSA and PAMPSAM were characterized by higher PDI in the range 0.728&ndash 0.959 and 0.658&ndash 0.836, respectively. The results confirmed the thermal sensitivity of the synthesized polymers and indicated a significant polydispersity and aggregation tendency of the resulting molecules. The conductivity results were applied for the interpretation of the polymerization process. |
| Databáze: | OpenAIRE |
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