Blunted fasting-induced decreases in plasma and CSF leptin concentrations in obese rats: the role of increased leptin secretion
Autor: | L Nguyen, R M O'Doherty |
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Rok vydání: | 2003 |
Předmět: |
Fasting induced
Leptin Male endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Adipose tissue Cerebrospinal fluid Internal medicine Gene expression Blood plasma medicine Animals Insulin Secretion Obesity Rats Wistar Nutrition and Dietetics Chemistry digestive oral and skin physiology Body Weight nutritional and metabolic diseases Fasting medicine.disease Rats Endocrinology Adipose Tissue hormones hormone substitutes and hormone antagonists |
Zdroj: | International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 28(1) |
Popis: | Fasting substantially decreases plasma leptin concentration. However, in obesity, the fasting-induced decrease in leptin concentration is blunted or absent. The objective of the current study was to determine in diet-induced obese (DIO) rats the contribution of altered leptin secretion and leptin expression to the blunted nutritional regulation of leptin concentration. Fasting-induced decreases in plasma leptin concentration were greater in lean (standard chow (SC)) rats compared to DIO (approximately 79 vs approximately 48%, P0.05 for DIO vs SC). CSF leptin was significantly reduced by fasting in SC (approximately 46%) but not in DIO. Fasting decreased adipose tissue leptin secretion in both SC and DIO, but the decrease was greater in SC (average approximately 74%) compared to DIO (average approximately 44%, P0.05, DIO vs SC). Additionally, leptin secretion in fasted DIO was substantially greater (average approximately 175%) than in fasted SC (P0.05). Adipose tissue leptin protein content was increased by approximately 80% in DIO compared to SC (P0.05). We conclude that a probable cause of blunted fasting-induced decreases in leptin concentration in obesity is elevated leptin secretion, which possibly results from increased leptin gene expression. |
Databáze: | OpenAIRE |
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