Apparent free cortisol concentrations in patients with anorexia nervosa at different stages of the disease
| Autor: | Giovanna Andreani, S. De Vescovi, Aldo Clerico, M. Rolla, D. Belliti, M.G. Del Chicca, A. Andreoni |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
medicine.medical_specialty Anorexia Nervosa Adolescent Hydrocortisone Endocrinology Diabetes and Metabolism medicine.medical_treatment Radioimmunoassay Disease Dexamethasone Basal (phylogenetics) Endocrinology Internal medicine Medicine Humans Equilibrium dialysis Circadian rhythm business.industry Steroid hormone Anorexia nervosa (differential diagnoses) Female business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Journal of endocrinological investigation. 7(3) |
| ISSN: | 0391-4097 |
| Popis: | We have measured the total cortisol concentration (TC) and the apparent free cortisol concentration (AFCC) in plasma samples of 17 patients with anorexia nervosa (AN) at different stages of the disease, in basal conditions and after suppression test. We measured free cortisol values directly by a RIA method in dialyzed plasma samples after an equilibrium dialysis system. We have found significantly elevated TC and AFCC values in basal conditions and after suppression test only in the group of patients in the severe stage of the disease. In addition, a significant (p less than 0.05) correlation existed between percent loss of ideal body weight TC and AFCC values after suppression test. Our results suggest that the hypothalamus-pituitary-adrenal axis may be grossly impaired only in the severe stage of AN. |
| Databáze: | OpenAIRE |
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