Retrospective multicenter evaluation of patients diagnosed with mucosal melanoma: a study of Anatolian Society of Medical Oncology
| Autor: | Sernaz Uzunoglu, Arife Ulas, Mukremin Uysal, Mahmut Gumus, Ibrahim Vedat Bayoglu, Ahmet Alacacioglu, Turkan Ozturk Topcu, Sebnem Yaman, Dincer Aydin, Melike Ozcelik, Ozlem Ercelep, Ozge Gumussay, Asude Aksoy, Burcu Yapar Taskoylu, Halil Kavgaci, Ahmet Siyar Ekinci, Oktay Bozkurt, Sinan Koca |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Male Adult Aged Aged 80 and over Female Humans Melanoma/*mortality/pathology/surgery Middle Aged Mucous Membrane/pathology Neoplasm Staging Retrospective Studies Survival Rate retrospective study very elderly Anorectal Turkey (republic) 0302 clinical medicine middle aged rectum mucosal melanoma Stage (cooking) mucosa Melanoma Univariate analysis urogenital system adult Mucosal melanoma clinical trial General Medicine interferon aged female priority journal 030220 oncology & carcinogenesis cancer surgery medicine.medical_specialty Prognostic variable overall survival Article cancer chemotherapy lung 03 medical and health sciences Head and neck Internal medicine medicine cancer radiotherapy follow up human upper gastrointestinal tract Survival rate Mucous Membrane business.industry Genitourinary system cancer staging Cancer lactate dehydrogenase anus head medicine.disease bleeding major clinical study neck mortality 030104 developmental biology multicenter study Cutaneous melanoma Genitourinary pathology prognosis business |
| Popis: | Mucosal melanoma (MM) is a rare type of cancer that differs significantly from cutaneous melanoma. In this study, we aimed to evaluate clinical and demographical characteristics, prognoses and factors influencing survival, treatment alternatives, and features of different subtypes of the patients. The patients were followed up with and treated in different centers due to their diagnoses of MM. We retrospectively analyzed data of 107 patients who were diagnosed with MM in 14 different institutions in Turkey. The mean age of the patients was 64.5 years. Of the patients, 47 % were female and 53 % were male. The median overall survival (OS) was 17 months, and the mean follow-up duration was 27 months. The 2-year survival rate was 42 %, and the 5-year survival rate was 23 %. The best survival rate appeared in those patients with MM in the head-neck region (median survival rate was 27 months, P = 0.034). The most common anatomical site was the head-neck region. In a univariate analysis, variables including age ≥65 years, the anatomical site of the primary lesion other than head and neck region, the metastatic stage of the disease, high levels of lactate dehydrogenase (LDH), and an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of ≥1 were found to be associated with poor survival (P < 0.05). However, in a multivariate analysis, only advanced stage disease (HR = 2.70; 95 % CI, 1.64–4.45; P = 0.000) and high LDH levels (HR = 2.31; 95 % CI, 1.40–3.80; P = 0.001) were determined to be adverse prognostic variables. Primary MM presents a more aggressive behavior and offers a poorer prognosis compared to cutaneous melanoma. Because the disease is rarely seen, is heterogeneous, and lacks randomized studies, issues concerning optimal treatment approaches and management and clinical characteristics of the disease have not been clarified yet. © 2016, International Society of Oncology and BioMarkers (ISOBM). |
| Databáze: | OpenAIRE |
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