Stem cell ageing of the root apical meristem of Arabidopsis thaliana
| Autor: | Thomas Laux, Annika Wein, Anne-Laure Le Gac |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Meristem Arabidopsis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Arabidopsis thaliana Stem Cell Niche Induced pluripotent stem cell Abscisic acid Cellular Senescence Plant Proteins Homeodomain Proteins Columella biology Arabidopsis Proteins Stem Cells biology.organism_classification Cell biology 030104 developmental biology Plant Root Cap chemistry Seedlings Plant hormone Stem cell Cell Division 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 190:111313 |
| ISSN: | 0047-6374 |
| Popis: | Plants form new organs from pluripotent stem cells throughout their lives and under changing environmental conditions. In the Arabidopsis root meristem, a pool of stem cells surrounding a stem cell organizer, named Quiescent Center (QC), gives rise to the specific root tissues. Among them, the columella stem cell niche that gives rise to the gravity-sensing columella cells has been used as a model system to study stem cell regulation at the young seedling stage. However, little is known about the changes of the stem cell niche during later development. Here, we report that the columella stem cell niche undergoes pronounced histological and molecular reorganization as the plant progresses towards the adult stage. Commonly-used reporters for cellular states undergo re-patterning after an initial juvenile meristem phase. Furthermore, the responsiveness to the plant hormone abscisic acid, an integrator of stress response, strongly decreases. Many ageing effects are reminiscent of the loss-of-function phenotype of the central stem cell regulator WOX5 and can be explained by gradually decreasing WOX5 expression levels during ageing. Our results show that the architecture and central regulatory components of the root stem cell niche are already highly dynamic within the first weeks of development. |
| Databáze: | OpenAIRE |
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