From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis
| Autor: | Madeleine Duc Dodon, Julien Villaudy, Louis Gazzolo, Eugénie Bagdassarian, Sébastien This, Eléonore Pérès, Dominique Rigal |
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| Rok vydání: | 2015 |
| Předmět: |
T-cell leukemia
lcsh:QR1-502 Mice SCID Review Disease medicine.disease_cause lcsh:Microbiology Adult T-cell leukemia/lymphoma humanized mouse models Pathogenesis Mice Retrovirus oncogenesis hemic and lymphatic diseases Virology medicine Animals Humans Leukemia-Lymphoma Adult T-Cell adult T cell leukemia/lymphoma Immunodeficiency Human T-lymphotropic virus 1 biology business.industry biology.organism_classification medicine.disease Disease Models Animal Infectious Diseases HTLV-1 Host-Pathogen Interactions Immunology Carcinogenesis business Neuroscience |
| Zdroj: | Viruses, Vol 7, Iss 12, Pp 6371-6386 (2015) Viruses |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v7122944 |
| Popis: | The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed. |
| Databáze: | OpenAIRE |
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