High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder
| Autor: | Takafumi Yokota, Jun Toda, Hirohiko Shibayama, Koichi Ohshima, Tetsuo Maeda, Kenji Oritani, Hiroaki Miyoshi, Hideaki Saito, Masao Mizuki, Naoki Hosen, Masao Seto, Shinsuke Kusakabe, Michiko Ichii, Jiro Fujita, Kentaro Fukushima, Yuzuru Kanakura |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Programmed Cell Death 1 Receptor chemical and pharmacologic phenomena Post-transplant lymphoproliferative disorder 03 medical and health sciences Young Adult 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating hemic and lymphatic diseases Internal medicine Medicine Humans Risk factor Aged Retrospective Studies Hematology business.industry Tumor-infiltrating lymphocytes Hematopoietic Stem Cell Transplantation FOXP3 hemic and immune systems Forkhead Transcription Factors Organ Transplantation Middle Aged medicine.disease Lymphoproliferative Disorders Transplantation surgical procedures operative 030220 oncology & carcinogenesis Immunology Female Lymphoma Large B-Cell Diffuse business Complication 030215 immunology |
| Zdroj: | International journal of hematology. 114(1) |
| ISSN: | 1865-3774 |
| Popis: | Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication of transplantation. In addition to reactivation of Epstein–Barr virus in immunocompromised patients, impaired tumor immunity is suggested to be a risk factor for PTLD. However, it remains unclear whether immune suppressive tumor-infiltrating lymphocytes (TILs) correlate with the occurrence or prognosis of PTLD. We analyzed TILs in 26 patients with PTLD to elucidate the clinicopathological significance of the expression of PD-1 and FoxP3, which are associated with exhausted T-cells and regulatory T-cells (Tregs), respectively. Numbers of PD-1+ TILs in the PTLD specimens were significantly higher in patients who developed PTLD early after transplantation (P = 0.0040), while numbers of FoxP3+ TILs were not (P = 0.184). There was no difference in overall response rate regardless of the expression of PD-1 or FoxP3. FoxP3high patients tended to have a shorter time to progression compared with FoxP3low patients, especially in the case of FoxP3high patients with diffuse large B-cell lymphoma-subtype PTLD (P = 0.011), while PD-1high patients did not. These results suggest that T-cell exhaustion may be mainly associated with PTLD development, while immune suppression by Tregs may be dominant in enhanced progression of PTLD following disease occurrence. |
| Databáze: | OpenAIRE |
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